Cancer, meta-analysis and reporting biases: the case of erythropoiesis-stimulating agents
نویسندگان
چکیده
منابع مشابه
Erythropoiesis stimulating agents and reno-protection: a meta-analysis
BACKGROUND Erythropoiesis stimulating agents (ESAs) were proposed to enhance survival of renal tissues through direct effects via activation of EPO receptors on renal cells resulting in reduced cell apoptosis, or indirect effects via increased oxygen delivery due to increased numbers of Hb containing red blood cells. Thus through several mechanisms there may be benefit of ESA administration on ...
متن کاملErythropoiesis-stimulating agents in the management of cancer patients with anemia: a meta-analysis.
BACKGROUND Erythropoiesis-stimulating agents (ESAs) are widely used in the management of anemia in cancer patients. Despite their apparent effectiveness, recent studies have suggested that ESAs could result in serious adverse events and even higher mortality. The aim of the current study was to evaluate the benefits and risks of ESAs in the management of cancer patients with anemia using a meta...
متن کاملBenefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis.
BACKGROUND Erythropoiesis-stimulating agents are used to treat anemia in patients with cancer. However, their safety and effectiveness is controversial. We did a systematic review of the clinical efficacy and harms of these agents in adults with anemia related to cancer or chemotherapy. METHODS We conducted a systematic review of published and unpublished randomized controlled trials (RCTs) u...
متن کاملSafety and efficacy outcomes with erythropoiesis-stimulating agents in patients with breast cancer: a meta-analysis.
BACKGROUND New data on erythropoiesis-stimulating agents (ESAs) regarding overall survival and disease progression-related outcomes in patients with breast cancer receiving chemotherapy are presented in a meta-analysis of controlled trials of ESA use (epoetin α, epoetin β, darbepoetin α, biosimilars). PATIENTS AND METHODS A literature search identified reports from January 1997 through March ...
متن کاملTwist and shout: one decade of meta-analyses of erythropoiesis-stimulating agents in cancer patients.
Anemia associated with cancer and cancer therapy is a common and important issue in the treatment of patients with malignant disease. Conventionally, blood transfusions are used to treat severe cancer-related anemia. Short- and long-acting preparations of recombinant human erythropoiesis-stimulating agents (ESAs) offer an alternative treatment option. Multiple studies and subsequent meta-analys...
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ژورنال
عنوان ژورنال: Swiss Medical Weekly
سال: 2013
ISSN: 1424-7860,1424-3997
DOI: 10.4414/smw.2013.13776